Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_1632	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages, natural killer cells	cell compartment	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1632	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages, natural killer cells	cell compartment	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1633	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages, natural killer cells	cell compartment	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1633	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages, natural killer cells	cell compartment	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1634	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	pDCs	TLR7 signalling via the adaptor MYD88	P58681.fasta	P58681	1050	activation of either nuclear factor-Œ∫B (NF-Œ∫B) or IFN-regulatory factor 7 (IRF7), which are transcription factors that are responsible for stimulating the expression of pro-inflammatory cytokines and type I IFNs, respectively.	NA	24762827	2014	Pubchem_assay
PRRID_1634	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	pDCs	TLR7 signalling via the adaptor MYD88	P58681.fasta	P58681	1050	activation of either nuclear factor-Œ∫B (NF-Œ∫B) or IFN-regulatory factor 7 (IRF7), which are transcription factors that are responsible for stimulating the expression of pro-inflammatory cytokines and type I IFNs, respectively.	NA	24762827	2014	Pubchem_assay
PRRID_1635	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	pDCs	TLR7 signalling via the adaptor MYD88	Q9NYK1.fasta	Q9NYK1	1049	activation of either nuclear factor-Œ∫B (NF-Œ∫B) or IFN-regulatory factor 7 (IRF7), which are transcription factors that are responsible for stimulating the expression of pro-inflammatory cytokines and type I IFNs, respectively.	NA	24762827	2014	Pubchem_assay
PRRID_1635	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	pDCs	TLR7 signalling via the adaptor MYD88	Q9NYK1.fasta	Q9NYK1	1049	activation of either nuclear factor-Œ∫B (NF-Œ∫B) or IFN-regulatory factor 7 (IRF7), which are transcription factors that are responsible for stimulating the expression of pro-inflammatory cytokines and type I IFNs, respectively.	NA	24762827	2014	Pubchem_assay
PRRID_1636	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	monocyte/macrophages	LRR- and pyrin domain-containing 3 (NLRP3)	P58682.fasta	P58682	1032	production of IL-12 but not IFNŒ±	NA	24762827	2014	Pubchem_assay
PRRID_1636	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	monocyte/macrophages	LRR- and pyrin domain-containing 3 (NLRP3)	P58682.fasta	P58682	1032	production of IL-12 but not IFNŒ±	NA	24762827	2014	Pubchem_assay
PRRID_1637	single-stranded RNA Click for more detail	herpes simplex virus (virus)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	extracellular domains of leucine-rich repeat motifs	P58681.fasta	P58681	1050	important role in the immune response to viral infection	NA	24754320	2014	Pubchem_assay
PRRID_1637	single-stranded RNA Click for more detail	herpes simplex virus (virus)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	extracellular domains of leucine-rich repeat motifs	P58681.fasta	P58681	1050	important role in the immune response to viral infection	NA	24754320	2014	Pubchem_assay
PRRID_1638	single-stranded RNA Click for more detail	herpes simplex virus (virus)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	extracellular domains of leucine-rich repeat motifs	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	NA	24754320	2014	Pubchem_assay
PRRID_1638	single-stranded RNA Click for more detail	herpes simplex virus (virus)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	extracellular domains of leucine-rich repeat motifs	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	NA	24754320	2014	Pubchem_assay
PRRID_1639	single-stranded RNA Click for more detail	herpes simplex virus (virus)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, mast cells	extracellular domains of leucine-rich repeat motifs	P58682.fasta	P58682	1032	important role in the immune response to viral infection	NA	24754320	2014	Pubchem_assay
PRRID_1639	single-stranded RNA Click for more detail	herpes simplex virus (virus)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, mast cells	extracellular domains of leucine-rich repeat motifs	P58682.fasta	P58682	1032	important role in the immune response to viral infection	NA	24754320	2014	Pubchem_assay
PRRID_1640	single-stranded RNA Click for more detail	herpes simplex virus (virus)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, mast cells	extracellular domains of leucine-rich repeat motifs	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	NA	24754320	2014	Pubchem_assay
PRRID_1640	single-stranded RNA Click for more detail	herpes simplex virus (virus)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, mast cells	extracellular domains of leucine-rich repeat motifs	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	NA	24754320	2014	Pubchem_assay
PRRID_1641	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Male BALB/c mice	Myeloid-derived suppressor cells (MDSCs)	Intracellular receptors	P58681.fasta	P58681	1050	important role in the immune response to viral infection	Functional assay	24748512	2014	Pubchem_assay
PRRID_1641	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Male BALB/c mice	Myeloid-derived suppressor cells (MDSCs)	Intracellular receptors	P58681.fasta	P58681	1050	important role in the immune response to viral infection	Functional assay	24748512	2014	Pubchem_assay
PRRID_1642	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Male BALB/c mice	Myeloid-derived suppressor cells (MDSCs)	Intracellular receptors	P58682.fasta	P58682	1032	important role in the immune response to viral infection	Functional assay	24748512	2014	Pubchem_assay
PRRID_1642	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Male BALB/c mice	Myeloid-derived suppressor cells (MDSCs)	Intracellular receptors	P58682.fasta	P58682	1032	important role in the immune response to viral infection	Functional assay	24748512	2014	Pubchem_assay
PRRID_1662	Unmethylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	24830024	2014	Pubchem_assay
PRRID_1662	Unmethylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	24830024	2014	Pubchem_assay
PRRID_1663	Unmethylated CpG DNA Click for more detail	Apoptotic cell(Bacteria)	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	ELISPOT assay, Proliferation assay	24828435	2014	Pubchem_assay
PRRID_1663	Unmethylated CpG DNA Click for more detail	Apoptotic cell(Bacteria)	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	ELISPOT assay, Proliferation assay	24828435	2014	Pubchem_assay
PRRID_1664	Unmethylated CpG DNA Click for more detail	Apoptotic cell(Bacteria)	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	ELISPOT assay, Proliferation assay	24828435	2014	Pubchem_assay
PRRID_1664	Unmethylated CpG DNA Click for more detail	Apoptotic cell(Bacteria)	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	ELISPOT assay, Proliferation assay	24828435	2014	Pubchem_assay
PRRID_1665	Unmethylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice (Murine)	Plasmacytoid dendritic cells (pDCs) within endosomal compartments	intracellular receptors	P58681.fasta	P58681	1050	important role in the immune response to viral infection	flow cytometry analysis, Immunofluorescence, Quantitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA	24814238	2014	Pubchem_assay
PRRID_1665	Unmethylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice (Murine)	Plasmacytoid dendritic cells (pDCs) within endosomal compartments	intracellular receptors	P58681.fasta	P58681	1050	important role in the immune response to viral infection	flow cytometry analysis, Immunofluorescence, Quantitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA	24814238	2014	Pubchem_assay
PRRID_1666	Unmethylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice (Murine)	Plasmacytoid dendritic cells (pDCs) within endosomal compartments	intracellular receptors	Q9NR96.fasta	Q9NR96	1032	important role in the immune response to viral infection	flow cytometry analysis, Immunofluorescence, Quantitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA	24814238	2014	Pubchem_assay
PRRID_1666	Unmethylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice (Murine)	Plasmacytoid dendritic cells (pDCs) within endosomal compartments	intracellular receptors	Q9NR96.fasta	Q9NR96	1032	important role in the immune response to viral infection	flow cytometry analysis, Immunofluorescence, Quantitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA	24814238	2014	Pubchem_assay
PRRID_1667	Unmethylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	cell compartment	Q9NR96.fasta	Q9NR96	1032	Possible effect in case of stroke i.e it is Involved in preconditioning and No protection after gene knockout following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1667	Unmethylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	cell compartment	Q9NR96.fasta	Q9NR96	1032	Possible effect in case of stroke i.e it is Involved in preconditioning and No protection after gene knockout following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1668	Unmethylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	cell compartment	Q9NR96.fasta	Q9NR96	1032	Possible effect in case of stroke i.e it is Involved in preconditioning and No protection after gene knockout following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1668	Unmethylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	cell compartment	Q9NR96.fasta	Q9NR96	1032	Possible effect in case of stroke i.e it is Involved in preconditioning and No protection after gene knockout following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1669	Unmethylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	act as adjuvants in vaccination strategies	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	C57BL/6 Mice	pDCs, macrophages	Cell Compartment/Intracellular (phagosomal compartment)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	24801628	2014	Pubchem_assay
PRRID_1669	Unmethylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	act as adjuvants in vaccination strategies	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	C57BL/6 Mice	pDCs, macrophages	Cell Compartment/Intracellular (phagosomal compartment)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	24801628	2014	Pubchem_assay
PRRID_1670	Unmethylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Male BALB/c mice	Myeloid-derived suppressor cells (MDSCs)	Intracellular receptors	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	Functional assay	24748512	2014	Pubchem_assay
PRRID_1670	Unmethylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Male BALB/c mice	Myeloid-derived suppressor cells (MDSCs)	Intracellular receptors	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	Functional assay	24748512	2014	Pubchem_assay
PRRID_1693	CpG-ODN 1826 Click for more detail	NA	5‚Äô-tccatgacgttcctgacgtt-3‚Äô	20	Nucleic Acid	Synthetic	TLR9 stimulation induces apoptosis of neurons via SARM1 signalling pathway	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	Primary cortical neurons	NA	Q9NR96.fasta	Q9NR96	1032	It resulted in neuronal apoptosis in primary cortical neuronal cultures and olfactory sensory neurons.	MTT assay	26423149	2015	Pubchem_assay
PRRID_1693	CpG-ODN 1826 Click for more detail	NA	5‚Äô-tccatgacgttcctgacgtt-3‚Äô	20	Nucleic Acid	Synthetic	TLR9 stimulation induces apoptosis of neurons via SARM1 signalling pathway	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	Primary cortical neurons	NA	Q9NR96.fasta	Q9NR96	1032	It resulted in neuronal apoptosis in primary cortical neuronal cultures and olfactory sensory neurons.	MTT assay	26423149	2015	Pubchem_assay
PRRID_1696	Imiquimod Click for more detail	NA	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	TLR7 stimulation induces apoptosis of neurons via SARM1 signalling pathway	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Primary cortical neurons	NA	P58681.fasta	P58681	1050	It resulted in neuronal apoptosis in primary cortical neuronal cultures and olfactory sensory neurons.	MTT assay	26423149	2015	Pubchem_assay
PRRID_1696	Imiquimod Click for more detail	NA	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	TLR7 stimulation induces apoptosis of neurons via SARM1 signalling pathway	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Primary cortical neurons	NA	P58681.fasta	P58681	1050	It resulted in neuronal apoptosis in primary cortical neuronal cultures and olfactory sensory neurons.	MTT assay	26423149	2015	Pubchem_assay
PRRID_1724	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Zebrafish	endosomes and lysosomes.	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	B3DJW3.fasta	B3DJW3	1057	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1724	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Zebrafish	endosomes and lysosomes.	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	B3DJW3.fasta	B3DJW3	1057	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1725	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 21 (TLR21)	Toll-like receptor (TLR)	Zebrafish	endosomes and lysosomes.	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	F1QMN8.fasta	F1QMN8	989	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1725	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 21 (TLR21)	Toll-like receptor (TLR)	Zebrafish	endosomes and lysosomes.	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	F1QMN8.fasta	F1QMN8	989	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1727	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	Immunostimulant	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Zebrafish	Plasma membrane	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	B8JIL3.fasta	B8JIL3	903	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1727	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	Immunostimulant	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Zebrafish	Plasma membrane	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	B8JIL3.fasta	B8JIL3	903	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1728	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	Immunostimulant	Toll-like receptor 22 (TLR22)	Toll-like receptor (TLR)	Zebrafish	endosomes and lysosomes.	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	B3DJL6.fasta	B3DJL6	947	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1728	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	Immunostimulant	Toll-like receptor 22 (TLR22)	Toll-like receptor (TLR)	Zebrafish	endosomes and lysosomes.	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	B3DJL6.fasta	B3DJL6	947	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1729	dsDNA Click for more detail	S. mansoni (others)	NA	NA	Nucleic Acid	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q9QUN7.fasta	Q9QUN7	784	TLR2-dependent induction of Tregs	NA	27120222	2016	Pubchem_assay
PRRID_1729	dsDNA Click for more detail	S. mansoni (others)	NA	NA	Nucleic Acid	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q9QUN7.fasta	Q9QUN7	784	TLR2-dependent induction of Tregs	NA	27120222	2016	Pubchem_assay
PRRID_1730	dsDNA Click for more detail	S. mansoni (others)	NA	NA	Nucleic Acid	Natural	Immunostimulant	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	NA	NA	Q99MB1.fasta	Q99MB1	905	TLR2-dependent induction of Tregs Activate STATÔõú	NA	27120222	2016	Pubchem_assay
PRRID_1730	dsDNA Click for more detail	S. mansoni (others)	NA	NA	Nucleic Acid	Natural	Immunostimulant	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	NA	NA	Q99MB1.fasta	Q99MB1	905	TLR2-dependent induction of Tregs Activate STATÔõú	NA	27120222	2016	Pubchem_assay
PRRID_1782	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Nucleic Acid	Synthetic	NA	CfLRRop-3	Leucine rich repeats (LRR)	NA	NA	NA	NA	NA	NA	NA	NA	26826425	2016	NA
PRRID_1782	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Nucleic Acid	Synthetic	NA	CfLRRop-3	Leucine rich repeats (LRR)	NA	NA	NA	NA	NA	NA	NA	NA	26826425	2016	NA
PRRID_1847	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Zebrafish	Plasma membrane	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	B8JIL3.fasta	B8JIL3	903	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1847	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Zebrafish	Plasma membrane	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	B8JIL3.fasta	B8JIL3	903	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1848	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 22 (TLR22)	Toll-like receptor (TLR)	Zebrafish	endosomes and lysosomes.	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	B3DJL6.fasta	B3DJL6	947	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1848	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 22 (TLR22)	Toll-like receptor (TLR)	Zebrafish	endosomes and lysosomes.	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	B3DJL6.fasta	B3DJL6	947	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1849	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	CnToll-like receptor 1 (TLR-1)	Toll-like receptor (TLR)	Chlamys nobilis	mantle, he- mocytes, gill, kidney, gonad, hepatopancreas	five leucine-rich repeats (LRR), two LRR-C-terminal (LRRCT) motifs and a LRR-N-terminal (LRRNT) motif in the extracellular domain, a transmembrane domain and a Toll/Interleukin-1 Receptor (TIR) of 138	NA	NA	NA	binds to microbes and act as PRR.	qRT-PCR	27403592	2016	NA
PRRID_1849	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	CnToll-like receptor 1 (TLR-1)	Toll-like receptor (TLR)	Chlamys nobilis	mantle, he- mocytes, gill, kidney, gonad, hepatopancreas	five leucine-rich repeats (LRR), two LRR-C-terminal (LRRCT) motifs and a LRR-N-terminal (LRRNT) motif in the extracellular domain, a transmembrane domain and a Toll/Interleukin-1 Receptor (TIR) of 138	NA	NA	NA	binds to microbes and act as PRR.	qRT-PCR	27403592	2016	NA
PRRID_1850	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	NA	NA	O15455.fasta	O15455	904	TLR3 (Poly I:C)-mediated, NO-dependent antiviral response [89] in murine embryonic fibroblasts	NA	27233799	2016	Pubchem_assay
PRRID_1850	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	NA	NA	O15455.fasta	O15455	904	TLR3 (Poly I:C)-mediated, NO-dependent antiviral response [89] in murine embryonic fibroblasts	NA	27233799	2016	Pubchem_assay
PRRID_1851	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	MmiToll-like receptor 13 (TLR13)	Toll-like receptor (TLR)	miiuy croaker	liver, spleen, and kidney,	TIR domain	NA	NA	NA	actives the ISRE	Luciferase assay	26952767	2016	NA
PRRID_1851	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	MmiToll-like receptor 13 (TLR13)	Toll-like receptor (TLR)	miiuy croaker	liver, spleen, and kidney,	TIR domain	NA	NA	NA	actives the ISRE	Luciferase assay	26952767	2016	NA
PRRID_1852	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	LcNTC	C type Lectin (CTL/CLR)	Larimichthys crocea	liver, spleen and head-kidney	CRD with four conserved disulfide-bonded cysteine residues (Cys -Cys , Cys -Cys ) and EPN/AND motifs	NA	NA	NA	Serve as a PRR involved in fish defense against virus, bacteria and parasites infection through recognizing carbohydrates on the surface of pathogens.	Bacterial agglutination assay	26828263	2016	NA
PRRID_1852	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	LcNTC	C type Lectin (CTL/CLR)	Larimichthys crocea	liver, spleen and head-kidney	CRD with four conserved disulfide-bonded cysteine residues (Cys -Cys , Cys -Cys ) and EPN/AND motifs	NA	NA	NA	Serve as a PRR involved in fish defense against virus, bacteria and parasites infection through recognizing carbohydrates on the surface of pathogens.	Bacterial agglutination assay	26828263	2016	NA
PRRID_1853	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	OfGal-1	galectin-1	Oplegnathus fasciatus	gills, head kidney, and liver.	NA	NA	NA	NA	OfGal-1 can recognize a wide range of microbes and is a vital pattern recognition receptor in the innate immune system of rock bream.	NA	26792759	2016	NA
PRRID_1853	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	OfGal-1	galectin-1	Oplegnathus fasciatus	gills, head kidney, and liver.	NA	NA	NA	NA	OfGal-1 can recognize a wide range of microbes and is a vital pattern recognition receptor in the innate immune system of rock bream.	NA	26792759	2016	NA
PRRID_1894	5‚-dsRNA Click for more detail	EBOV, MV, SeV, NDV, RSV, flu virus, hantavirus,VSV, RV, HCV, JEV, adenovirus, vaccinia virus, HSV,L.	NA	NA	Nucleic Acid	Natural	K63-polyubiquitination/ polyubiquitin chain binding mediated receptor tetramerization	RIG-1	Rig-like receptor (RLR)	Human	Cytoplasm, all mammalian cell types	NA	O95786.fasta	O95786	925	MAVS-TRAF3-TBK1/ IKKe-IRF3. MAVS-FADD/ TRAF6-IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_1894	5‚-dsRNA Click for more detail	EBOV, MV, SeV, NDV, RSV, flu virus, hantavirus,VSV, RV, HCV, JEV, adenovirus, vaccinia virus, HSV,L.	NA	NA	Nucleic Acid	Natural	K63-polyubiquitination/ polyubiquitin chain binding mediated receptor tetramerization	RIG-1	Rig-like receptor (RLR)	Human	Cytoplasm, all mammalian cell types	NA	O95786.fasta	O95786	925	MAVS-TRAF3-TBK1/ IKKe-IRF3. MAVS-FADD/ TRAF6-IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_1984	CL097 Click for more detail	SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus)	CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)N	NA	Nucleic Acid	Synthetic	Z-loop proteolytic cleavage, and receptor dimer conformational change	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Endosomes. pDCs and B cells	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_1984	CL097 Click for more detail	SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus)	CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)N	NA	Nucleic Acid	Synthetic	Z-loop proteolytic cleavage, and receptor dimer conformational change	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Endosomes. pDCs and B cells	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_1985	CL097 Click for more detail	SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus)	CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)N	NA	Nucleic Acid	Synthetic	Z-loop proteolytic cleavage, and receptor dimer conformational change	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	Endosomes. Monocytes, macrophages and cDCs	Leucine-rich Repeat (LRR) Domain	Q9NR97.fasta	Q9NR97	1041	MyD88-IRAK4/ IRAK1-IRAF6- IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_1985	CL097 Click for more detail	SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus)	CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)N	NA	Nucleic Acid	Synthetic	Z-loop proteolytic cleavage, and receptor dimer conformational change	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	Endosomes. Monocytes, macrophages and cDCs	Leucine-rich Repeat (LRR) Domain	Q9NR97.fasta	Q9NR97	1041	MyD88-IRAK4/ IRAK1-IRAF6- IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_1988	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	Oral carcinogenesis	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	squamous cell carcinomas	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	interferon-Œ≤ production and activation of caspases 3 and 9	NA	28982847	2017	Pubchem_assay
PRRID_1988	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	Oral carcinogenesis	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	squamous cell carcinomas	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	interferon-Œ≤ production and activation of caspases 3 and 9	NA	28982847	2017	Pubchem_assay
PRRID_2001	DNA Click for more detail	All vertebrates(others)	NA	NA	Nucleic Acid	Natural	Cellular injury and necrosis	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NRN6	154	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_2001	DNA Click for more detail	All vertebrates(others)	NA	NA	Nucleic Acid	Natural	Cellular injury and necrosis	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NRN6	154	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_2002	DNA Click for more detail	All vertebrates(others)	NA	NA	Nucleic Acid	Natural	Cellular injury and necrosis	AIM2	Pattern recognition receptor (PRR)	Human	NA	NA	O14862.fasta	O14862	343	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_2002	DNA Click for more detail	All vertebrates(others)	NA	NA	Nucleic Acid	Natural	Cellular injury and necrosis	AIM2	Pattern recognition receptor (PRR)	Human	NA	NA	O14862.fasta	O14862	343	Activate NF-KB	NA	28049142	2017	Pubchem_assay
PRRID_2003	DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	NA	AIM2	Pattern recognition receptor (PRR)	NA	NA	NA	NA	NA	NA	NA	NA	28063015	2017	NA
PRRID_2003	DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	NA	AIM2	Pattern recognition receptor (PRR)	NA	NA	NA	NA	NA	NA	NA	NA	28063015	2017	NA
PRRID_2004	DNA Click for more detail	NA	NA	NA	Nucleic Acid	Natural	induce the secretion of IL-12, IL-8, and IFN-Œ± in human dendritic cells.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	Dendritic cells	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NRN6	154	NA	NA	28961019	2017	Pubchem_assay
PRRID_2004	DNA Click for more detail	NA	NA	NA	Nucleic Acid	Natural	induce the secretion of IL-12, IL-8, and IFN-Œ± in human dendritic cells.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	Dendritic cells	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NRN6	154	NA	NA	28961019	2017	Pubchem_assay
PRRID_2005	DNA Click for more detail	NA	NA	NA	Nucleic Acid	Natural	induce the secretion of IL-12, IL-8, and IFN-Œ± in human dendritic cells.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	dendritic cells	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	NA	NA	28961019	2017	Pubchem_assay
PRRID_2005	DNA Click for more detail	NA	NA	NA	Nucleic Acid	Natural	induce the secretion of IL-12, IL-8, and IFN-Œ± in human dendritic cells.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	dendritic cells	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	NA	NA	28961019	2017	Pubchem_assay
PRRID_2006	DNA Click for more detail	NA	NA	NA	Nucleic Acid	Natural	induce the secretion of IL-12, IL-8, and IFN-Œ± in human dendritic cells.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	dendritic cells	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	NA	NA	28961019	2017	Pubchem_assay
PRRID_2006	DNA Click for more detail	NA	NA	NA	Nucleic Acid	Natural	induce the secretion of IL-12, IL-8, and IFN-Œ± in human dendritic cells.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	dendritic cells	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	NA	NA	28961019	2017	Pubchem_assay
PRRID_2007	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	viral infection	Melanoma differentiation -associated gene 5 (MDA5)	Pattern recognition receptor (PRR)	Human	mitochondrial outer membrane	(CARDs), a DEAD/H box RNA helicase domain, and a C-terminal domain (CTD).	Q53TB6.fasta	Q53TB6	435	NA	NA	29069650	2017	Pubchem_assay
PRRID_2007	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	viral infection	Melanoma differentiation -associated gene 5 (MDA5)	Pattern recognition receptor (PRR)	Human	mitochondrial outer membrane	(CARDs), a DEAD/H box RNA helicase domain, and a C-terminal domain (CTD).	Q53TB6.fasta	Q53TB6	435	NA	NA	29069650	2017	Pubchem_assay
PRRID_2008	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	NA	NA	O15455.fasta	O15455	904	NA	NA	29066255	2017	Pubchem_assay
PRRID_2008	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	NA	NA	O15455.fasta	O15455	904	NA	NA	29066255	2017	Pubchem_assay
PRRID_2009	dsRNA Click for more detail	Hepatitis C Virus (virus)	NA	NA	Nucleic Acid	Natural	Activation of NOD1	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Mice	Macrophages	nucleotide-binding oligomerization domain	Q8BHB0.fasta	Q8BHB0	953	Independent of MAVS; likely dsRNA produced by NS5B polymerase	NA	28823510	2017	Pubchem_assay
PRRID_2009	dsRNA Click for more detail	Hepatitis C Virus (virus)	NA	NA	Nucleic Acid	Natural	Activation of NOD1	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Mice	Macrophages	nucleotide-binding oligomerization domain	Q8BHB0.fasta	Q8BHB0	953	Independent of MAVS; likely dsRNA produced by NS5B polymerase	NA	28823510	2017	Pubchem_assay
PRRID_2010	dsRNA Click for more detail	NA	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	28801521	2017	NA
PRRID_2010	dsRNA Click for more detail	NA	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	28801521	2017	NA

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